Presets are unselectable and when I select effect they do not do anything

I am playing left 4 dead to and I installed the latest of reshade 6.5.1 and it loaded fine but when I tried changing the preset to another that I had it would not let me select it and only stayed on the default reshade preset and when I select other effects it would not load them and my game would look how it was when I had no reshade. Can someone help me?